Drug interactions
Drospirenone + Sulfadiazine
Severity: Minor
Drospirenone and Sulfadiazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonamides can contribute to hyperkalemia, and drospirenone has anti-mineralocorticoid, potassium-sparing activity. Together they may add to the risk of raised serum potassium, especially in patients with renal impairment or other potassium-raising therapy.
What this interaction means in plain words
Drospirenone and Sulfadiazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive hyperkalemia risk from drospirenone's anti-mineralocorticoid effect and sulfonamide-related reduced renal potassium excretion.
What to do
Check serum potassium in patients with renal impairment or those taking other potassium-raising drugs when a prolonged sulfadiazine course is given with drospirenone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Drospirenone and Sulfadiazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Sulfadiazine?
MediHelp rates the interaction as minor. Drospirenone and Sulfadiazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfonamides can contribute to hyperkalemia, and drospirenone has anti-mineralocorticoid, potassium-sparing activity. Together they may add to the risk of raised serum potassium, especially in patients with renal impairment or other potassium-raising therapy.
How serious is the interaction between Drospirenone and Sulfadiazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium in patients with renal impairment or those taking other potassium-raising drugs when a prolonged sulfadiazine course is given with drospirenone.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
