Drug interactions
Drospirenone + Telmisartan-amlodipine
Severity: Moderate
Drospirenone and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and retains potassium, as does telmisartan. Together they can raise serum potassium, particularly in patients with renal impairment or other hyperkalemia risks.
What this interaction means in plain words
Drospirenone and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Additive potassium retention from angiotensin receptor blockade and drospirenone's antimineralocorticoid effect.
What to do
Check serum potassium during the first cycle of combined use and periodically thereafter. Consider an alternative contraceptive in patients with renal impairment or high baseline potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Drospirenone and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and retains potassium, as does telmisartan. Together they can raise serum potassium, particularly in patients with renal impairment or other hyperkalemia risks.
How serious is the interaction between Drospirenone and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first cycle of combined use and periodically thereafter. Consider an alternative contraceptive in patients with renal impairment or high baseline potassium.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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