Drug interactions
Drospirenone + Tofacitinib
Severity: Minor
Drospirenone and Tofacitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone is a CYP3A4 substrate and a weak inhibitor in vitro, but no meaningful effect on tofacitinib exposure is expected at contraceptive doses. The interaction is theoretical.
What this interaction means in plain words
Drospirenone and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Drospirenone belongs to Endocrine; Tofacitinib belongs to Musculoskeletal.
Why it happens
Weak, theoretical CYP3A4 inhibition by drospirenone; not shown to be clinically relevant.
What to do
No dose adjustment is needed. Be aware that both tofacitinib and estrogen-containing contraceptives carry thrombotic risk in susceptible patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Tofacitinib?
MediHelp rates the interaction as minor. Drospirenone and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone is a CYP3A4 substrate and a weak inhibitor in vitro, but no meaningful effect on tofacitinib exposure is expected at contraceptive doses. The interaction is theoretical.
How serious is the interaction between Drospirenone and Tofacitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Be aware that both tofacitinib and estrogen-containing contraceptives carry thrombotic risk in susceptible patients.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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