Drug interactions
Drospirenone + Ulipristal
Severity: Moderate
Drospirenone and Ulipristal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ulipristal is a progesterone receptor modulator and may reduce the contraceptive efficacy of hormonal contraceptives containing progestins such as drospirenone if they are started or resumed soon after its use. Its own emergency contraceptive effect could also be diminished by progestin exposure.
What this interaction means in plain words
Drospirenone and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at the progesterone receptor between ulipristal and the progestin.
What to do
Delay starting or resuming drospirenone for at least 5 days after ulipristal and use a reliable barrier method until the pill has been taken for the required days after restarting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Ulipristal?
MediHelp rates the interaction as moderate. Drospirenone and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ulipristal is a progesterone receptor modulator and may reduce the contraceptive efficacy of hormonal contraceptives containing progestins such as drospirenone if they are started or resumed soon after its use. Its own emergency contraceptive effect could also be diminished by progestin exposure.
How serious is the interaction between Drospirenone and Ulipristal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Delay starting or resuming drospirenone for at least 5 days after ulipristal and use a reliable barrier method until the pill has been taken for the required days after restarting.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
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