Drug interactions
Durvalumab + Siponimod
Severity: Moderate
Durvalumab and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Durvalumab enhances immune activity rather than suppressing it, but immune-related adverse events are often treated with immunosuppressants, and siponimod lowers lymphocytes. The combination may blunt anti-tumor immunity and raise infection risk, though evidence is limited.
What this interaction means in plain words
Durvalumab and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Durvalumab belongs to Oncology; Siponimod belongs to Central Nervous System.
Why it happens
Pharmacodynamic opposition: siponimod sequesters lymphocytes that checkpoint blockade relies on; the exact clinical effect is not well established.
What to do
Monitor lymphocyte counts and infections, and review the need for siponimod in patients on checkpoint inhibitors. Consult oncology and neurology before combining.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Other interactions of Durvalumab
Frequently asked questions
Can I take Durvalumab with Siponimod?
MediHelp rates the interaction as moderate. Durvalumab and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Durvalumab enhances immune activity rather than suppressing it, but immune-related adverse events are often treated with immunosuppressants, and siponimod lowers lymphocytes. The combination may blunt anti-tumor immunity and raise infection risk, though evidence is limited.
How serious is the interaction between Durvalumab and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lymphocyte counts and infections, and review the need for siponimod in patients on checkpoint inhibitors. Consult oncology and neurology before combining.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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