Drug interactions
Echothiophate iodide + Nortriptyline
Severity: Minor
Echothiophate iodide and Nortriptyline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Echothiophate is a cholinesterase inhibitor given as an ophthalmic agent, while nortriptyline has antimuscarinic effects that may oppose it. Systemic absorption of the eye drops is low, so the clinical effect is likely small, although some reduction in ocular effect is plausible.
What this interaction means in plain words
Echothiophate iodide and Nortriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic opposition between cholinesterase inhibition and muscarinic blockade.
What to do
Monitor intraocular pressure and pupil response, and no routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Echothiophate iodide with Nortriptyline?
MediHelp rates the interaction as minor. Echothiophate iodide and Nortriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Echothiophate is a cholinesterase inhibitor given as an ophthalmic agent, while nortriptyline has antimuscarinic effects that may oppose it. Systemic absorption of the eye drops is low, so the clinical effect is likely small, although some reduction in ocular effect is plausible.
How serious is the interaction between Echothiophate iodide and Nortriptyline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor intraocular pressure and pupil response, and no routine dose change is needed.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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