Drug interactions
Efavirenz + Ergoloid mesylates
Severity: Major
Efavirenz and Ergoloid mesylates: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may raise ergoloid levels, increasing the risk of ergot toxicity such as vasospasm and ischemia. Ergot interactions with CYP3A4-affecting antiretrovirals are considered dangerous.
What this interaction means in plain words
Efavirenz and Ergoloid mesylates can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Efavirenz alters CYP3A4 activity, thereby impairing ergoloid metabolism and increasing exposure.
What to do
Avoid the combination and use an alternative agent for the ergoloid indication. If it is given, monitor for peripheral ischemia, paresthesia and cold extremities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Ergoloid mesylates?
MediHelp rates the interaction as major. Efavirenz and Ergoloid mesylates can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Efavirenz may raise ergoloid levels, increasing the risk of ergot toxicity such as vasospasm and ischemia. Ergot interactions with CYP3A4-affecting antiretrovirals are considered dangerous.
How serious is the interaction between Efavirenz and Ergoloid mesylates?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative agent for the ergoloid indication. If it is given, monitor for peripheral ischemia, paresthesia and cold extremities.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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