Drug interactions
Efavirenz + Glecaprevir / pibrentasvir
Severity: Contraindicated
Efavirenz and Glecaprevir / pibrentasvir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz substantially lowers glecaprevir and pibrentasvir exposure, which may cause hepatitis C treatment failure. Labeling advises against combined use.
What this interaction means in plain words
Efavirenz and Glecaprevir / pibrentasvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Efavirenz induces CYP3A4 and P-glycoprotein, increasing clearance of both components.
What to do
Do not coadminister; switch to an alternative antiretroviral before HCV therapy. Check current labeling for compatible regimens.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as contraindicated. Efavirenz and Glecaprevir / pibrentasvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Efavirenz substantially lowers glecaprevir and pibrentasvir exposure, which may cause hepatitis C treatment failure. Labeling advises against combined use.
How serious is the interaction between Efavirenz and Glecaprevir / pibrentasvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; switch to an alternative antiretroviral before HCV therapy. Check current labeling for compatible regimens.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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