Drug interactions
Efavirenz + Hydroxyprogesterone caproate
Severity: Moderate
Efavirenz and Hydroxyprogesterone caproate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyprogesterone caproate is partly cleared by CYP3A4, so efavirenz may lower its concentrations. The clinical significance is uncertain but reduced efficacy is possible.
What this interaction means in plain words
Efavirenz and Hydroxyprogesterone caproate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Efavirenz induces CYP3A4, increasing the metabolism of hydroxyprogesterone caproate.
What to do
Monitor for reduced therapeutic effect; no routine dose adjustment is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Hydroxyprogesterone caproate?
MediHelp rates the interaction as moderate. Efavirenz and Hydroxyprogesterone caproate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyprogesterone caproate is partly cleared by CYP3A4, so efavirenz may lower its concentrations. The clinical significance is uncertain but reduced efficacy is possible.
How serious is the interaction between Efavirenz and Hydroxyprogesterone caproate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced therapeutic effect; no routine dose adjustment is established.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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