Drug interactions
Efavirenz + Isradipine
Severity: Moderate
Efavirenz and Isradipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may reduce isradipine concentrations, leading to weaker blood pressure control. The QT-related concern is minimal and mostly theoretical.
What this interaction means in plain words
Efavirenz and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Efavirenz induces CYP3A4, increasing the first-pass and systemic metabolism of isradipine.
What to do
Monitor blood pressure and titrate isradipine upward if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Isradipine?
MediHelp rates the interaction as moderate. Efavirenz and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz may reduce isradipine concentrations, leading to weaker blood pressure control. The QT-related concern is minimal and mostly theoretical.
How serious is the interaction between Efavirenz and Isradipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and titrate isradipine upward if control is lost.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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