Drug interactions
Efavirenz + Ixabepilone
Severity: Moderate
Efavirenz and Ixabepilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ixabepilone is a CYP3A4 substrate, and strong inducers can lower its exposure and efficacy. Efavirenz is a moderate inducer, so a reduction is plausible.
What this interaction means in plain words
Efavirenz and Ixabepilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Efavirenz induces CYP3A4, increasing the metabolism of ixabepilone.
What to do
Avoid combining where possible and consider an alternative antiretroviral. If it cannot be avoided, monitor oncologic response and toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Ixabepilone?
MediHelp rates the interaction as moderate. Efavirenz and Ixabepilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ixabepilone is a CYP3A4 substrate, and strong inducers can lower its exposure and efficacy. Efavirenz is a moderate inducer, so a reduction is plausible.
How serious is the interaction between Efavirenz and Ixabepilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible and consider an alternative antiretroviral. If it cannot be avoided, monitor oncologic response and toxicity.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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