Drug interactions
Efavirenz + Ketamine
Severity: Minor
Efavirenz and Ketamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may reduce ketamine concentrations through CYP3A4 and CYP2B6 induction, possibly lessening its anesthetic or analgesic effect. Both drugs also affect the CNS.
What this interaction means in plain words
Efavirenz and Ketamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Efavirenz belongs to Anti Virals; Ketamine belongs to Central Nervous System.
Why it happens
Enzyme induction by efavirenz increases ketamine metabolism, with possible additive CNS effects.
What to do
Titrate ketamine to clinical effect and monitor sedation and psychiatric effects. No fixed dose adjustment is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Ketamine
Frequently asked questions
Can I take Efavirenz with Ketamine?
MediHelp rates the interaction as minor. Efavirenz and Ketamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Efavirenz may reduce ketamine concentrations through CYP3A4 and CYP2B6 induction, possibly lessening its anesthetic or analgesic effect. Both drugs also affect the CNS.
How serious is the interaction between Efavirenz and Ketamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate ketamine to clinical effect and monitor sedation and psychiatric effects. No fixed dose adjustment is required.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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