Drug interactions
Efavirenz + Levosalbutamol
Severity: Minor
Efavirenz and Levosalbutamol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz can prolong the QT interval, particularly at higher exposures, and high doses of beta-2 agonists can add to QT effects and cause hypokalemia. The combined risk of arrhythmia is probably small at usual inhaled doses but is greater with other risk factors.
What this interaction means in plain words
Efavirenz and Levosalbutamol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Efavirenz belongs to Anti Virals; Levosalbutamol belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization, with beta-agonist-induced hypokalemia potentially increasing susceptibility.
What to do
No routine action is needed at usual inhaled doses. Check potassium and consider an ECG if high or frequent levosalbutamol doses are used or if other QT-prolonging drugs or electrolyte disturbances are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levosalbutamol
Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Levosalbutamol?
MediHelp rates the interaction as minor. Efavirenz and Levosalbutamol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Efavirenz can prolong the QT interval, particularly at higher exposures, and high doses of beta-2 agonists can add to QT effects and cause hypokalemia. The combined risk of arrhythmia is probably small at usual inhaled doses but is greater with other risk factors.
How serious is the interaction between Efavirenz and Levosalbutamol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed at usual inhaled doses. Check potassium and consider an ECG if high or frequent levosalbutamol doses are used or if other QT-prolonging drugs or electrolyte disturbances are present.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
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