Drug interactions
Efavirenz + Olodaterol inhaled
Severity: Minor
Efavirenz and Olodaterol inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz can prolong the QT interval, and long-acting beta-agonists such as olodaterol can affect cardiac repolarisation and cause hypokalemia and tachycardia. Systemic exposure from the inhaled dose is low, so the combined effect is usually small. Risk is higher in patients with other QT risk factors.
What this interaction means in plain words
Efavirenz and Olodaterol inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive pharmacodynamic effects on cardiac repolarisation and heart rate.
What to do
No routine change is needed. Consider ECG and potassium monitoring in patients with existing QT risk factors or heart disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Olodaterol inhaled?
MediHelp rates the interaction as minor. Efavirenz and Olodaterol inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Efavirenz can prolong the QT interval, and long-acting beta-agonists such as olodaterol can affect cardiac repolarisation and cause hypokalemia and tachycardia. Systemic exposure from the inhaled dose is low, so the combined effect is usually small. Risk is higher in patients with other QT risk factors.
How serious is the interaction between Efavirenz and Olodaterol inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Consider ECG and potassium monitoring in patients with existing QT risk factors or heart disease.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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