Drug interactions
Efavirenz + Quinupristin / dalfopristin
Severity: Minor
Efavirenz and Quinupristin / dalfopristin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4, which could modestly raise efavirenz exposure. Efavirenz is also metabolized mainly by CYP2B6, so the effect is likely small and the combination is short-term.
What this interaction means in plain words
Efavirenz and Quinupristin / dalfopristin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Quinupristin/dalfopristin inhibits CYP3A4, a minor pathway of efavirenz metabolism.
What to do
No dose change is usually needed. Monitor for efavirenz CNS adverse effects during therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Quinupristin / dalfopristin?
MediHelp rates the interaction as minor. Efavirenz and Quinupristin / dalfopristin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinupristin/dalfopristin inhibits CYP3A4, which could modestly raise efavirenz exposure. Efavirenz is also metabolized mainly by CYP2B6, so the effect is likely small and the combination is short-term.
How serious is the interaction between Efavirenz and Quinupristin / dalfopristin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for efavirenz CNS adverse effects during therapy.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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