Drug interactions
Efavirenz + Sufentanil sl
Severity: Moderate
Efavirenz and Sufentanil sl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may lower sufentanil concentrations, reducing analgesia and possibly causing withdrawal in opioid-dependent patients. Stopping efavirenz later may raise sufentanil levels and cause respiratory depression.
What this interaction means in plain words
Efavirenz and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by efavirenz increases sufentanil clearance.
What to do
Monitor analgesia and signs of withdrawal during co-use. Watch for sedation and respiratory depression after efavirenz is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Sufentanil sl?
MediHelp rates the interaction as moderate. Efavirenz and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz may lower sufentanil concentrations, reducing analgesia and possibly causing withdrawal in opioid-dependent patients. Stopping efavirenz later may raise sufentanil levels and cause respiratory depression.
How serious is the interaction between Efavirenz and Sufentanil sl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesia and signs of withdrawal during co-use. Watch for sedation and respiratory depression after efavirenz is discontinued.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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