Drug interactions
Efavirenz + Telotristat ethyl
Severity: Minor
Efavirenz and Telotristat ethyl: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telotristat is reported to induce CYP3A4 and might lower exposure to some co-administered substrates. The effect on efavirenz, which relies mainly on CYP2B6, is not well characterised and is probably small.
What this interaction means in plain words
Efavirenz and Telotristat ethyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible enzyme induction by telotristat; the effect on efavirenz is not firmly established.
What to do
Monitor the HIV virologic response during co-administration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Telotristat ethyl?
MediHelp rates the interaction as minor. Efavirenz and Telotristat ethyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Telotristat is reported to induce CYP3A4 and might lower exposure to some co-administered substrates. The effect on efavirenz, which relies mainly on CYP2B6, is not well characterised and is probably small.
How serious is the interaction between Efavirenz and Telotristat ethyl?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the HIV virologic response during co-administration.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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