Drug interactions
Efavirenz + Teniposide
Severity: Moderate
Efavirenz and Teniposide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teniposide is metabolised by CYP3A4, and efavirenz induction may increase its clearance and reduce its exposure. This could reduce its antineoplastic effect.
What this interaction means in plain words
Efavirenz and Teniposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Efavirenz induces CYP3A4, increasing teniposide metabolism.
What to do
Monitor the clinical response and toxicity of the chemotherapy regimen. Consider an alternative antiretroviral such as an integrase inhibitor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Teniposide?
MediHelp rates the interaction as moderate. Efavirenz and Teniposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teniposide is metabolised by CYP3A4, and efavirenz induction may increase its clearance and reduce its exposure. This could reduce its antineoplastic effect.
How serious is the interaction between Efavirenz and Teniposide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the clinical response and toxicity of the chemotherapy regimen. Consider an alternative antiretroviral such as an integrase inhibitor.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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