Drug interactions
Efavirenz + Tenofovir disoproxil
Severity: Minor
Efavirenz and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
These agents are routinely co-prescribed in a standard HIV regimen. Immune reconstitution inflammatory syndrome can occur with any effective antiretroviral therapy and is not a specific interaction between these two drugs. No pharmacokinetic or clinically meaningful pharmacodynamic interaction is expected.
What this interaction means in plain words
Efavirenz and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No relevant pharmacokinetic or pharmacodynamic interaction is established between these drugs.
What to do
No dose adjustment is required. Monitor patients with advanced immunosuppression for IRIS after starting antiretroviral therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Efavirenz and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. These agents are routinely co-prescribed in a standard HIV regimen. Immune reconstitution inflammatory syndrome can occur with any effective antiretroviral therapy and is not a specific interaction between these two drugs. No pharmacokinetic or clinically meaningful pharmacodynamic interaction is expected.
How serious is the interaction between Efavirenz and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Monitor patients with advanced immunosuppression for IRIS after starting antiretroviral therapy.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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