Drug interactions
Efavirenz + Umeclidinium bromide / vilanterol inhaled
Severity: Minor
Efavirenz and Umeclidinium bromide / vilanterol inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may lower vilanterol exposure through CYP3A4 induction, though low systemic levels from inhalation make this of limited importance. Both drugs may affect QT, but systemic exposure from the inhaled product is small.
What this interaction means in plain words
Efavirenz and Umeclidinium bromide / vilanterol inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Efavirenz induces CYP3A4 metabolism of vilanterol, with possible additive QT effects.
What to do
No routine adjustment is needed. Monitor bronchodilator response and consider an ECG in patients with existing QT risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as minor. Efavirenz and Umeclidinium bromide / vilanterol inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Efavirenz may lower vilanterol exposure through CYP3A4 induction, though low systemic levels from inhalation make this of limited importance. Both drugs may affect QT, but systemic exposure from the inhaled product is small.
How serious is the interaction between Efavirenz and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor bronchodilator response and consider an ECG in patients with existing QT risk factors.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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