Drug interactions
Efavirenz + Vorapaxar
Severity: Moderate
Efavirenz and Vorapaxar: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz induces CYP3A4, which is the main pathway for vorapaxar clearance, so antiplatelet exposure may fall. Reduced effect could weaken protection against thrombotic events.
What this interaction means in plain words
Efavirenz and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Efavirenz induction of CYP3A4 increases vorapaxar metabolism.
What to do
Avoid combining vorapaxar with strong CYP3A4 inducers where possible. Consider an alternative antiplatelet strategy if efavirenz is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Vorapaxar?
MediHelp rates the interaction as moderate. Efavirenz and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz induces CYP3A4, which is the main pathway for vorapaxar clearance, so antiplatelet exposure may fall. Reduced effect could weaken protection against thrombotic events.
How serious is the interaction between Efavirenz and Vorapaxar?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining vorapaxar with strong CYP3A4 inducers where possible. Consider an alternative antiplatelet strategy if efavirenz is required.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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