Drug interactions
Efavirenz + Zolpidem
Severity: Minor
Efavirenz and Zolpidem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may reduce zolpidem exposure, which could weaken its hypnotic effect. Efavirenz itself causes sleep disturbance and vivid dreams, which may complicate assessment of response.
What this interaction means in plain words
Efavirenz and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Efavirenz belongs to Anti Virals; Zolpidem belongs to Central Nervous System.
Why it happens
Efavirenz induces CYP3A4, the main pathway of zolpidem metabolism.
What to do
Assess hypnotic response and adjust zolpidem within labeled limits only if needed. Counsel on next-day impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Zolpidem
Frequently asked questions
Can I take Efavirenz with Zolpidem?
MediHelp rates the interaction as minor. Efavirenz and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Efavirenz may reduce zolpidem exposure, which could weaken its hypnotic effect. Efavirenz itself causes sleep disturbance and vivid dreams, which may complicate assessment of response.
How serious is the interaction between Efavirenz and Zolpidem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess hypnotic response and adjust zolpidem within labeled limits only if needed. Counsel on next-day impairment.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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