Drug interactions
Efgartigimod alfa + Ramucirumab
Severity: Moderate
Efgartigimod alfa and Ramucirumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efgartigimod blocks the neonatal Fc receptor, which recycles IgG, so it may increase clearance of IgG1 antibodies such as ramucirumab and reduce exposure.
What this interaction means in plain words
Efgartigimod alfa and Ramucirumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efgartigimod alfa belongs to Miscellaneous; Ramucirumab belongs to Oncology.
Why it happens
FcRn blockade reduces IgG recycling and shortens the half-life of IgG monoclonal antibodies.
What to do
Monitor for reduced ramucirumab efficacy; consider alternatives if prolonged combined therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramucirumab
Other interactions of Efgartigimod alfa
- Adalimumab + Efgartigimod alfa Moderate
- Ado-trastuzumab + Efgartigimod alfa Moderate
- Basiliximab + Efgartigimod alfa Moderate
- Bevacizumab + Efgartigimod alfa Moderate
- Brentuximab + Efgartigimod alfa Moderate
- Denosumab + Efgartigimod alfa Moderate
Frequently asked questions
Can I take Efgartigimod alfa with Ramucirumab?
MediHelp rates the interaction as moderate. Efgartigimod alfa and Ramucirumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efgartigimod blocks the neonatal Fc receptor, which recycles IgG, so it may increase clearance of IgG1 antibodies such as ramucirumab and reduce exposure.
How serious is the interaction between Efgartigimod alfa and Ramucirumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced ramucirumab efficacy; consider alternatives if prolonged combined therapy is needed.
What other medicines interact with Ramucirumab?
MediHelp also lists interactions of Ramucirumab with, for example, Efgartigimod / hyaluronidase sc. The full list is on the Ramucirumab page.
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