Drug interactions
Bevacizumab + Efgartigimod alfa
Severity: Moderate
Bevacizumab and Efgartigimod alfa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efgartigimod blocks the neonatal Fc receptor, which normally recycles IgG, so it may speed clearance of IgG-based drugs. Bevacizumab is an IgG1 antibody and its exposure could fall.
What this interaction means in plain words
Bevacizumab and Efgartigimod alfa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bevacizumab belongs to Oncology; Efgartigimod alfa belongs to Miscellaneous.
Why it happens
FcRn blockade reduces IgG recycling and shortens the half-life of IgG monoclonal antibodies.
What to do
Monitor for reduced bevacizumab response; if prolonged therapy is essential, consider timing or alternatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bevacizumab
- Bevacizumab + Sunitinib Major
- Bevacizumab + Daunorubicin Moderate
- Bevacizumab + Dengue vaccine Moderate
- Bevacizumab + Doxorubicin Moderate
- Bevacizumab + Doxorubicin liposomal Moderate
- Bevacizumab + Efgartigimod / hyaluronidase sc Moderate
Other interactions of Efgartigimod alfa
- Adalimumab + Efgartigimod alfa Moderate
- Ado-trastuzumab + Efgartigimod alfa Moderate
- Basiliximab + Efgartigimod alfa Moderate
- Brentuximab + Efgartigimod alfa Moderate
- Denosumab + Efgartigimod alfa Moderate
- Efgartigimod alfa + Galcanezumab Moderate
Frequently asked questions
Can I take Bevacizumab with Efgartigimod alfa?
MediHelp rates the interaction as moderate. Bevacizumab and Efgartigimod alfa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efgartigimod blocks the neonatal Fc receptor, which normally recycles IgG, so it may speed clearance of IgG-based drugs. Bevacizumab is an IgG1 antibody and its exposure could fall.
How serious is the interaction between Bevacizumab and Efgartigimod alfa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced bevacizumab response; if prolonged therapy is essential, consider timing or alternatives.
What other medicines interact with Bevacizumab?
MediHelp also lists interactions of Bevacizumab with, for example, Sunitinib, Daunorubicin, Dengue vaccine. The full list is on the Bevacizumab page.
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