Drug interactions
Efgartigimod / hyaluronidase sc + Ipilimumab
Severity: Moderate
Efgartigimod / hyaluronidase sc and Ipilimumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Subcutaneous efgartigimod blocks the neonatal Fc receptor, which normally protects IgG antibodies from degradation. Ipilimumab is an IgG1 antibody, so its clearance could increase and exposure fall, potentially weakening antitumor effect. The clinical significance is uncertain.
What this interaction means in plain words
Efgartigimod / hyaluronidase sc and Ipilimumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Efgartigimod blocks FcRn-mediated IgG recycling, which may accelerate catabolism of IgG-based ipilimumab.
What to do
Avoid combining where possible, or monitor tumor response closely if efgartigimod is necessary. Involve oncology and neurology specialists in weighing alternatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipilimumab
- Etrasimod + Ipilimumab Major
- Ipilimumab + Vemurafenib Major
- Ciltacabtagene autoleucel + Ipilimumab Moderate
- Efgartigimod alfa + Ipilimumab Moderate
- Idecabtagene vicleucel + Ipilimumab Moderate
- Ipilimumab + Lisocabtagene maraleucel Moderate
Frequently asked questions
Can I take Efgartigimod / hyaluronidase sc with Ipilimumab?
MediHelp rates the interaction as moderate. Efgartigimod / hyaluronidase sc and Ipilimumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Subcutaneous efgartigimod blocks the neonatal Fc receptor, which normally protects IgG antibodies from degradation. Ipilimumab is an IgG1 antibody, so its clearance could increase and exposure fall, potentially weakening antitumor effect. The clinical significance is uncertain.
How serious is the interaction between Efgartigimod / hyaluronidase sc and Ipilimumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, or monitor tumor response closely if efgartigimod is necessary. Involve oncology and neurology specialists in weighing alternatives.
What other medicines interact with Ipilimumab?
MediHelp also lists interactions of Ipilimumab with, for example, Etrasimod, Vemurafenib, Ciltacabtagene autoleucel. The full list is on the Ipilimumab page.
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