Drug interactions
Etrasimod + Ipilimumab
Severity: Major
Etrasimod and Ipilimumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod is a sphingosine-1-phosphate receptor modulator that lowers circulating lymphocyte counts, and its labeling cautions against combining it with antineoplastic or immunomodulating drugs. Adding ipilimumab, which causes immune activation and often requires immunosuppressive treatment for toxicity, may lead to unpredictable immune effects and infection risk. Lymphocyte effects persist for weeks after etrasimod is stopped.
What this interaction means in plain words
Etrasimod and Ipilimumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Ipilimumab belongs to Oncology.
Why it happens
Additive immunomodulatory effects: etrasimod sequesters lymphocytes in lymphoid tissue while ipilimumab removes T-cell checkpoint inhibition.
What to do
Avoid combining where an alternative exists, including for several weeks after stopping etrasimod. If unavoidable, monitor for infection and immune-related adverse events and check lymphocyte counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ipilimumab
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Ipilimumab?
MediHelp rates the interaction as major. Etrasimod and Ipilimumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod is a sphingosine-1-phosphate receptor modulator that lowers circulating lymphocyte counts, and its labeling cautions against combining it with antineoplastic or immunomodulating drugs. Adding ipilimumab, which causes immune activation and often requires immunosuppressive treatment for toxicity, may lead to unpredictable immune effects and infection risk. Lymphocyte effects persist for weeks after etrasimod is stopped.
How serious is the interaction between Etrasimod and Ipilimumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where an alternative exists, including for several weeks after stopping etrasimod. If unavoidable, monitor for infection and immune-related adverse events and check lymphocyte counts.
What other medicines interact with Ipilimumab?
MediHelp also lists interactions of Ipilimumab with, for example, Vemurafenib, Ciltacabtagene autoleucel, Efgartigimod / hyaluronidase sc. The full list is on the Ipilimumab page.
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