Drug interactions
Efgartigimod / hyaluronidase sc + Rituximab
Severity: Moderate
Efgartigimod / hyaluronidase sc and Rituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efgartigimod blocks FcRn and lowers IgG, which may reduce exposure to IgG-based monoclonal antibodies such as rituximab. Rituximab's effect might therefore be diminished.
What this interaction means in plain words
Efgartigimod / hyaluronidase sc and Rituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
FcRn blockade reduces IgG recycling and increases clearance of rituximab.
What to do
Monitor for reduced rituximab efficacy, and consider timing rituximab dosing away from efgartigimod cycles. If rituximab is essential long term, review efgartigimod use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rituximab
Frequently asked questions
Can I take Efgartigimod / hyaluronidase sc with Rituximab?
MediHelp rates the interaction as moderate. Efgartigimod / hyaluronidase sc and Rituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efgartigimod blocks FcRn and lowers IgG, which may reduce exposure to IgG-based monoclonal antibodies such as rituximab. Rituximab's effect might therefore be diminished.
How serious is the interaction between Efgartigimod / hyaluronidase sc and Rituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced rituximab efficacy, and consider timing rituximab dosing away from efgartigimod cycles. If rituximab is essential long term, review efgartigimod use.
What other medicines interact with Rituximab?
MediHelp also lists interactions of Rituximab with, for example, Adenovirus types 4 and 7 live, Baricitinib, Certolizumab pegol. The full list is on the Rituximab page.
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