Drug interactions
Efgartigimod / hyaluronidase sc + Tocilizumab
Severity: Moderate
Efgartigimod / hyaluronidase sc and Tocilizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efgartigimod blocks the neonatal Fc receptor and reduces circulating IgG, which may also lower the exposure to tocilizumab, an IgG1 antibody. This could reduce disease control.
What this interaction means in plain words
Efgartigimod / hyaluronidase sc and Tocilizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
FcRn blockade accelerates degradation of IgG-based drugs such as tocilizumab.
What to do
Monitor for reduced tocilizumab effectiveness and consider an alternative therapy if long-term use of tocilizumab is essential.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tocilizumab
- Bcg vaccine live + Tocilizumab Contraindicated
- Measles mumps and rubella vaccine live + Tocilizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Tocilizumab Contraindicated
- Measles vaccine + Tocilizumab Contraindicated
- Rubella vaccine + Tocilizumab Contraindicated
- Smallpox vaccine live + Tocilizumab Contraindicated
Frequently asked questions
Can I take Efgartigimod / hyaluronidase sc with Tocilizumab?
MediHelp rates the interaction as moderate. Efgartigimod / hyaluronidase sc and Tocilizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efgartigimod blocks the neonatal Fc receptor and reduces circulating IgG, which may also lower the exposure to tocilizumab, an IgG1 antibody. This could reduce disease control.
How serious is the interaction between Efgartigimod / hyaluronidase sc and Tocilizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced tocilizumab effectiveness and consider an alternative therapy if long-term use of tocilizumab is essential.
What other medicines interact with Tocilizumab?
MediHelp also lists interactions of Tocilizumab with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Tocilizumab page.
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