Drug interactions
Efgartigimod / hyaluronidase sc + Trastuzumab
Severity: Moderate
Efgartigimod / hyaluronidase sc and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efgartigimod blocks the neonatal Fc receptor, which normally protects IgG from degradation. Trastuzumab is an IgG1 antibody, so its exposure and effect could be reduced.
What this interaction means in plain words
Efgartigimod / hyaluronidase sc and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition at the neonatal Fc receptor accelerates IgG catabolism and may lower trastuzumab concentrations.
What to do
Monitor for reduced trastuzumab efficacy. If trastuzumab is essential long term, consider whether efgartigimod can be stopped or an alternative used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trastuzumab
Frequently asked questions
Can I take Efgartigimod / hyaluronidase sc with Trastuzumab?
MediHelp rates the interaction as moderate. Efgartigimod / hyaluronidase sc and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efgartigimod blocks the neonatal Fc receptor, which normally protects IgG from degradation. Trastuzumab is an IgG1 antibody, so its exposure and effect could be reduced.
How serious is the interaction between Efgartigimod / hyaluronidase sc and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced trastuzumab efficacy. If trastuzumab is essential long term, consider whether efgartigimod can be stopped or an alternative used.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.
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