Drug interactions
Elbasvir / grazoprevir + Fluvastatin
Severity: Moderate
Elbasvir / grazoprevir and Fluvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grazoprevir inhibits OATP1B1/3 and BCRP, which can increase exposure to statins. Fluvastatin is affected less than some other statins but the risk of myopathy may rise.
What this interaction means in plain words
Elbasvir / grazoprevir and Fluvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Grazoprevir inhibits hepatic OATP1B1/3 and intestinal BCRP, decreasing statin clearance and increasing absorption.
What to do
Use the lowest effective fluvastatin dose during treatment and monitor for muscle pain or weakness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporine + Fluvastatin Major
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
Frequently asked questions
Can I take Elbasvir / grazoprevir with Fluvastatin?
MediHelp rates the interaction as moderate. Elbasvir / grazoprevir and Fluvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Grazoprevir inhibits OATP1B1/3 and BCRP, which can increase exposure to statins. Fluvastatin is affected less than some other statins but the risk of myopathy may rise.
How serious is the interaction between Elbasvir / grazoprevir and Fluvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective fluvastatin dose during treatment and monitor for muscle pain or weakness.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Fluvastatin page.
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