Drug interactions
Elivaldogene autotemcel + Raltegravir
Severity: Major
Elivaldogene autotemcel and Raltegravir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antiretroviral drugs can interfere with lentiviral transduction during manufacture of this gene therapy. Raltegravir present during mobilization or apheresis could compromise product quality.
What this interaction means in plain words
Elivaldogene autotemcel and Raltegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Antiretroviral activity inhibits lentiviral vector transduction of harvested cells.
What to do
Stop raltegravir at least one month before mobilization, allow for drug elimination, and keep it stopped until all apheresis cycles are complete. Plan alternative HIV control with specialists.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Raltegravir
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Raltegravir Contraindicated
- Aluminum hydroxide / magnesium carbonate + Raltegravir Major
- Aluminum hydroxide / magnesium trisilicate + Raltegravir Major
- Aluminum hydroxide + Raltegravir Major
- Atidarsagene autotemcel + Raltegravir Major
- Betibeglogene autotemcel + Raltegravir Major
Frequently asked questions
Can I take Elivaldogene autotemcel with Raltegravir?
MediHelp rates the interaction as major. Elivaldogene autotemcel and Raltegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antiretroviral drugs can interfere with lentiviral transduction during manufacture of this gene therapy. Raltegravir present during mobilization or apheresis could compromise product quality.
How serious is the interaction between Elivaldogene autotemcel and Raltegravir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop raltegravir at least one month before mobilization, allow for drug elimination, and keep it stopped until all apheresis cycles are complete. Plan alternative HIV control with specialists.
What other medicines interact with Raltegravir?
MediHelp also lists interactions of Raltegravir with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Aluminum hydroxide / magnesium carbonate, Aluminum hydroxide / magnesium trisilicate. The full list is on the Raltegravir page.
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