Drug interactions
Acetaminophen + Eltrombopag
Severity: Minor
Acetaminophen and Eltrombopag: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits UGT enzymes in vitro, which could slightly raise acetaminophen exposure. Clinical significance is unclear, though both drugs can affect the liver.
What this interaction means in plain words
Acetaminophen and Eltrombopag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of UGT-mediated glucuronidation of acetaminophen by eltrombopag.
What to do
No routine adjustment is needed at usual acetaminophen doses. Monitor liver tests per eltrombopag labeling and avoid high acetaminophen doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Acetaminophen with Eltrombopag?
MediHelp rates the interaction as minor. Acetaminophen and Eltrombopag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag inhibits UGT enzymes in vitro, which could slightly raise acetaminophen exposure. Clinical significance is unclear, though both drugs can affect the liver.
How serious is the interaction between Acetaminophen and Eltrombopag?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed at usual acetaminophen doses. Monitor liver tests per eltrombopag labeling and avoid high acetaminophen doses.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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