Drug interactions
Elvitegravir + Ketoconazole
Severity: Moderate
Elvitegravir and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole and cobicistat-boosted elvitegravir raise each other's concentrations. Ketoconazole exposure increases notably, raising the risk of hepatic and other azole adverse effects.
What this interaction means in plain words
Elvitegravir and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat and ketoconazole are both CYP3A4 inhibitors and substrates, so mutual metabolic inhibition increases exposure.
What to do
Limit ketoconazole to no more than 200 mg daily when combined with the boosted regimen. Monitor liver function and for azole adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Elvitegravir with Ketoconazole?
MediHelp rates the interaction as moderate. Elvitegravir and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole and cobicistat-boosted elvitegravir raise each other's concentrations. Ketoconazole exposure increases notably, raising the risk of hepatic and other azole adverse effects.
How serious is the interaction between Elvitegravir and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit ketoconazole to no more than 200 mg daily when combined with the boosted regimen. Monitor liver function and for azole adverse effects.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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