Drug interactions
Elvitegravir + Lorlatinib
Severity: Major
Elvitegravir and Lorlatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elvitegravir is cleared by CYP3A4, and lorlatinib may lower its concentrations. This may compromise viral suppression and promote resistance.
What this interaction means in plain words
Elvitegravir and Lorlatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Lorlatinib induces CYP3A4, increasing elvitegravir metabolism.
What to do
Avoid the combination if possible and consider an antiretroviral not reliant on CYP3A4 boosting. If it is used, monitor HIV RNA closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Elvitegravir with Lorlatinib?
MediHelp rates the interaction as major. Elvitegravir and Lorlatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Elvitegravir is cleared by CYP3A4, and lorlatinib may lower its concentrations. This may compromise viral suppression and promote resistance.
How serious is the interaction between Elvitegravir and Lorlatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and consider an antiretroviral not reliant on CYP3A4 boosting. If it is used, monitor HIV RNA closely.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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