Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Emtricitabine
Severity: Contraindicated
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Emtricitabine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination product already contains emtricitabine, so a separate emtricitabine dose is a straightforward duplication. It offers no benefit and exposes the patient to an excess dose.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Emtricitabine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Therapeutic duplication of the same active ingredient, leading to excess exposure.
What to do
Do not co-administer; the fixed-dose tablet already supplies emtricitabine. Remove the separate emtricitabine product from the regimen.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Emtricitabine
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Emtricitabine?
MediHelp rates the interaction as contraindicated. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Emtricitabine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The combination product already contains emtricitabine, so a separate emtricitabine dose is a straightforward duplication. It offers no benefit and exposes the patient to an excess dose.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Emtricitabine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; the fixed-dose tablet already supplies emtricitabine. Remove the separate emtricitabine product from the regimen.
What other medicines interact with Emtricitabine?
MediHelp also lists interactions of Emtricitabine with, for example, Atidarsagene autotemcel, Betibeglogene autotemcel, Elivaldogene autotemcel. The full list is on the Emtricitabine page.
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