Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Erlotinib
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Erlotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP3A4, the main route of erlotinib metabolism, and can increase erlotinib exposure. This may worsen rash, diarrhea and rarer toxicities such as interstitial lung disease.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Erlotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP3A4-mediated erlotinib metabolism.
What to do
Monitor for erlotinib toxicity and reduce the dose in steps if severe reactions occur, or choose an alternative antiretroviral regimen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Erlotinib?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Erlotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat inhibits CYP3A4, the main route of erlotinib metabolism, and can increase erlotinib exposure. This may worsen rash, diarrhea and rarer toxicities such as interstitial lung disease.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Erlotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erlotinib toxicity and reduce the dose in steps if severe reactions occur, or choose an alternative antiretroviral regimen.
What other medicines interact with Erlotinib?
MediHelp also lists interactions of Erlotinib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Erlotinib page.
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