Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluvastatin
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Fluvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elvitegravir may induce CYP2C9, which is the main pathway for fluvastatin, while cobicistat inhibits transporters such as BCRP and OATP1B1. Net effect on fluvastatin is uncertain and could be either lower efficacy or higher exposure.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Fluvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible CYP2C9 induction by elvitegravir opposed by transporter inhibition by cobicistat; net effect not established.
What to do
Monitor lipid response and muscle symptoms, and adjust the fluvastatin dose based on response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporine + Fluvastatin Major
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Fluvastatin?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Fluvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elvitegravir may induce CYP2C9, which is the main pathway for fluvastatin, while cobicistat inhibits transporters such as BCRP and OATP1B1. Net effect on fluvastatin is uncertain and could be either lower efficacy or higher exposure.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Fluvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipid response and muscle symptoms, and adjust the fluvastatin dose based on response.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Fluvastatin page.
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