Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Gliclazide
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elvitegravir may induce CYP2C9 while cobicistat inhibits some enzymes, so gliclazide exposure may change in an unpredictable direction. This could alter glycemic control.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Elvitegravir may induce CYP2C9 and cobicistat inhibits CYP3A and CYP2D6, with uncertain net effect on gliclazide metabolism.
What to do
Monitor blood glucose after starting or stopping the antiretroviral regimen and adjust gliclazide dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Gliclazide?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elvitegravir may induce CYP2C9 while cobicistat inhibits some enzymes, so gliclazide exposure may change in an unpredictable direction. This could alter glycemic control.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping the antiretroviral regimen and adjust gliclazide dose as needed.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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