Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Glipizide-metformin
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits OCT2 and MATE1 and can raise metformin concentrations, while elvitegravir has weak induction effects that may lower glipizide levels. Net effects on glucose control are variable.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits renal transporters involved in metformin elimination, and elvitegravir may modestly induce CYP2C9, which metabolizes glipizide.
What to do
Monitor blood glucose and renal function and watch for lactic acidosis symptoms. Adjust the metformin dose as needed and titrate glipizide to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Glipizide-metformin?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat inhibits OCT2 and MATE1 and can raise metformin concentrations, while elvitegravir has weak induction effects that may lower glipizide levels. Net effects on glucose control are variable.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function and watch for lactic acidosis symptoms. Adjust the metformin dose as needed and titrate glipizide to response.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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