Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Ibuprofen
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir disoproxil is eliminated renally and is associated with nephrotoxicity, and NSAIDs such as ibuprofen can reduce renal perfusion. Concurrent or high-dose NSAID use increases the risk of acute kidney injury and higher tenofovir exposure.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-induced reduction in renal blood flow plus competition for renal elimination adds to tenofovir tubular toxicity; cobicistat also raises serum creatinine.
What to do
Prefer paracetamol or alternatives to regular NSAIDs, and monitor serum creatinine and eGFR if NSAIDs are needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Ibuprofen?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir disoproxil is eliminated renally and is associated with nephrotoxicity, and NSAIDs such as ibuprofen can reduce renal perfusion. Concurrent or high-dose NSAID use increases the risk of acute kidney injury and higher tenofovir exposure.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer paracetamol or alternatives to regular NSAIDs, and monitor serum creatinine and eGFR if NSAIDs are needed.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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