Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Isosorbide mononitrate
Severity: Minor
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Isosorbide mononitrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isosorbide mononitrate is cleared mainly by non-CYP3A4 denitration and glucuronidation, so cobicistat is unlikely to change its exposure meaningfully. No clinically important interaction is expected.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Isosorbide mononitrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism; isosorbide mononitrate is not a significant CYP3A4 substrate.
What to do
No dose adjustment is needed; monitor blood pressure as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isosorbide mononitrate
- Avanafil + Isosorbide mononitrate Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Sildenafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide mononitrate Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Isosorbide mononitrate?
MediHelp rates the interaction as minor. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Isosorbide mononitrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isosorbide mononitrate is cleared mainly by non-CYP3A4 denitration and glucuronidation, so cobicistat is unlikely to change its exposure meaningfully. No clinically important interaction is expected.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Isosorbide mononitrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor blood pressure as usual.
What other medicines interact with Isosorbide mononitrate?
MediHelp also lists interactions of Isosorbide mononitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide mononitrate page.
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