Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lidocaine-prilocaine
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lidocaine-prilocaine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A inhibitor and can raise lidocaine concentrations. With topical lidocaine-prilocaine at small areas and short durations the systemic increase is modest, but larger applications could raise the risk of lidocaine toxicity and methemoglobinemia from prilocaine.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lidocaine-prilocaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP3A4, reducing the hepatic metabolism of lidocaine and prilocaine.
What to do
Limit application area, amount and duration of the cream. Watch for signs of lidocaine toxicity (dizziness, perioral numbness, arrhythmia) and cyanosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lidocaine-prilocaine
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Lidocaine-prilocaine?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lidocaine-prilocaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat is a strong CYP3A inhibitor and can raise lidocaine concentrations. With topical lidocaine-prilocaine at small areas and short durations the systemic increase is modest, but larger applications could raise the risk of lidocaine toxicity and methemoglobinemia from prilocaine.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Lidocaine-prilocaine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit application area, amount and duration of the cream. Watch for signs of lidocaine toxicity (dizziness, perioral numbness, arrhythmia) and cyanosis.
What other medicines interact with Lidocaine-prilocaine?
MediHelp also lists interactions of Lidocaine-prilocaine with, for example, Phenazopyridine, Bupivacaine implant, Bupivacaine liposome. The full list is on the Lidocaine-prilocaine page.
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