Drug interactions
Disopyramide + Lidocaine-prilocaine
Severity: Moderate
Disopyramide and Lidocaine-prilocaine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide and lidocaine both depress cardiac conduction and contractility, so combined systemic exposure could provoke arrhythmias or worsen heart failure. With topical lidocaine-prilocaine absorption is generally low, so the risk is mainly with large-area use or in patients with existing conduction disease or heart failure.
What this interaction means in plain words
Disopyramide and Lidocaine-prilocaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Disopyramide belongs to Cardiovascular; Lidocaine-prilocaine belongs to Genitourinary.
Why it happens
Additive pharmacodynamic effects on cardiac sodium channels, conduction and myocardial contractility.
What to do
Keep topical dosing within labeled limits in patients on disopyramide and monitor ECG and signs of heart failure if substantial absorption is possible. Take extra care in patients with conduction defects or reduced ventricular function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lidocaine-prilocaine
- Lidocaine-prilocaine + Phenazopyridine Major
- Bupivacaine implant + Lidocaine-prilocaine Moderate
- Bupivacaine liposome + Lidocaine-prilocaine Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lidocaine-prilocaine Moderate
- Lidocaine-prilocaine + Mexiletine Moderate
- Lidocaine-prilocaine + Nirmatrelvir / ritonavir Moderate
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Lidocaine-prilocaine?
MediHelp rates the interaction as moderate. Disopyramide and Lidocaine-prilocaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Disopyramide and lidocaine both depress cardiac conduction and contractility, so combined systemic exposure could provoke arrhythmias or worsen heart failure. With topical lidocaine-prilocaine absorption is generally low, so the risk is mainly with large-area use or in patients with existing conduction disease or heart failure.
How serious is the interaction between Disopyramide and Lidocaine-prilocaine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep topical dosing within labeled limits in patients on disopyramide and monitor ECG and signs of heart failure if substantial absorption is possible. Take extra care in patients with conduction defects or reduced ventricular function.
What other medicines interact with Lidocaine-prilocaine?
MediHelp also lists interactions of Lidocaine-prilocaine with, for example, Phenazopyridine, Bupivacaine implant, Bupivacaine liposome. The full list is on the Lidocaine-prilocaine page.
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