Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Meclofenamic acid
Severity: Major
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Meclofenamic acid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir is eliminated by the kidney and is nephrotoxic, and NSAIDs can reduce renal perfusion. Coadministration has been associated with acute kidney injury, and cobicistat further raises serum creatinine by inhibiting tubular secretion, which can mask changes.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Meclofenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive renal injury from NSAID-induced hemodynamic changes and tenofovir proximal tubular toxicity, with possible competition for renal elimination.
What to do
Use an alternative analgesic such as paracetamol; if an NSAID is necessary, use the lowest dose briefly and monitor creatinine, estimated clearance and phosphate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Meclofenamic acid?
MediHelp rates the interaction as major. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Meclofenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tenofovir is eliminated by the kidney and is nephrotoxic, and NSAIDs can reduce renal perfusion. Coadministration has been associated with acute kidney injury, and cobicistat further raises serum creatinine by inhibiting tubular secretion, which can mask changes.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Meclofenamic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative analgesic such as paracetamol; if an NSAID is necessary, use the lowest dose briefly and monitor creatinine, estimated clearance and phosphate.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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