Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Meloxicam
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir disoproxil is eliminated by the kidney and can cause proximal tubular toxicity, while NSAIDs reduce renal perfusion. Concomitant use, especially with high or repeated NSAID doses, has been associated with acute kidney injury. Cobicistat also raises serum creatinine by blocking tubular secretion, which can obscure monitoring.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity from NSAID-induced reduction in renal prostaglandin-dependent perfusion and tenofovir tubular toxicity, with shared renal elimination pathways.
What to do
Prefer non-NSAID analgesics such as paracetamol; if the NSAID is necessary, use the lowest dose briefly and monitor creatinine, estimated GFR and urine protein.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Meloxicam?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir disoproxil is eliminated by the kidney and can cause proximal tubular toxicity, while NSAIDs reduce renal perfusion. Concomitant use, especially with high or repeated NSAID doses, has been associated with acute kidney injury. Cobicistat also raises serum creatinine by blocking tubular secretion, which can obscure monitoring.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer non-NSAID analgesics such as paracetamol; if the NSAID is necessary, use the lowest dose briefly and monitor creatinine, estimated GFR and urine protein.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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