Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Nateglinide
Severity: Minor
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Nateglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a CYP3A4 and CYP2D6 inhibitor, and elvitegravir is a weak inducer of some enzymes. Nateglinide is metabolized mainly by CYP2C9 with a smaller CYP3A4 contribution, so the net effect on exposure is uncertain and probably small. Glycemic response may change.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible modest alteration of CYP2C9/CYP3A4 metabolism of nateglinide; net effect not well established.
What to do
Monitor blood glucose when the antiretroviral regimen is started or stopped. Adjust the nateglinide dose only if glycemic control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Nateglinide?
MediHelp rates the interaction as minor. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cobicistat is a CYP3A4 and CYP2D6 inhibitor, and elvitegravir is a weak inducer of some enzymes. Nateglinide is metabolized mainly by CYP2C9 with a smaller CYP3A4 contribution, so the net effect on exposure is uncertain and probably small. Glycemic response may change.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Nateglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when the antiretroviral regimen is started or stopped. Adjust the nateglinide dose only if glycemic control changes.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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