Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Nifedipine
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP3A4 and can substantially raise nifedipine exposure. This may cause excessive vasodilation with hypotension, flushing, headache and peripheral edema.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibition of CYP3A4-mediated metabolism of nifedipine.
What to do
Start with a lower nifedipine dose and titrate to blood pressure response, monitoring blood pressure and heart rate. Consider an alternative antihypertensive if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Nifedipine?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat inhibits CYP3A4 and can substantially raise nifedipine exposure. This may cause excessive vasodilation with hypotension, flushing, headache and peripheral edema.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a lower nifedipine dose and titrate to blood pressure response, monitoring blood pressure and heart rate. Consider an alternative antihypertensive if hypotension occurs.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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