Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Praziquantel
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Praziquantel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat may raise praziquantel concentrations, potentially increasing dose-related adverse effects such as dizziness, headache and gastrointestinal upset. Praziquantel is given as a short course, so the clinical impact is usually limited.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP3A4, reducing the first-pass and systemic metabolism of praziquantel.
What to do
Monitor for increased adverse effects during the short praziquantel course; no routine dose change is required, and the patient should avoid driving if dizzy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Praziquantel?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat may raise praziquantel concentrations, potentially increasing dose-related adverse effects such as dizziness, headache and gastrointestinal upset. Praziquantel is given as a short course, so the clinical impact is usually limited.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Praziquantel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased adverse effects during the short praziquantel course; no routine dose change is required, and the patient should avoid driving if dizzy.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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