Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Streptomycin
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir disoproxil and cobicistat can reduce renal function or raise serum creatinine, and tenofovir has been linked to tubular toxicity. Added to streptomycin, a nephrotoxic and ototoxic agent, the risk of renal injury rises and streptomycin may accumulate.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity, with renal impairment reducing streptomycin clearance.
What to do
Monitor serum creatinine, phosphate and urine protein regularly during combined use. Adjust streptomycin dose to renal function and monitor for hearing or vestibular symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Streptomycin
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Streptomycin?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir disoproxil and cobicistat can reduce renal function or raise serum creatinine, and tenofovir has been linked to tubular toxicity. Added to streptomycin, a nephrotoxic and ototoxic agent, the risk of renal injury rises and streptomycin may accumulate.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, phosphate and urine protein regularly during combined use. Adjust streptomycin dose to renal function and monitor for hearing or vestibular symptoms.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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