Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Timolol
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat in this combination inhibits CYP2D6, which metabolizes timolol. Timolol exposure may increase, leading to bradycardia, hypotension or AV block, especially with systemic dosing.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP2D6-mediated metabolism of timolol.
What to do
Monitor heart rate and blood pressure and reduce the timolol dose if needed. Use clinical judgment for ophthalmic timolol in patients with cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Timolol?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat in this combination inhibits CYP2D6, which metabolizes timolol. Timolol exposure may increase, leading to bradycardia, hypotension or AV block, especially with systemic dosing.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and reduce the timolol dose if needed. Use clinical judgment for ophthalmic timolol in patients with cardiac disease.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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